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Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease.
Suur BE, Chemaly M, Lindquist Liljeqvist M, Djordjevic D, Stenemo M, Bergman O, Karlöf E, Lengquist M, Odeberg J, Hurt-Camejo E, Eriksson P, Ketelhuth DFJ, Roy J, Hedin U, Nyberg M, Matic L. Suur BE, et al. Front Pharmacol. 2022 Sep 15;13:988561. doi: 10.3389/fphar.2022.988561. eCollection 2022. Front Pharmacol. 2022. PMID: 36188622 Free PMC article.
Apart from PCSK4, all PCSK family members lie in genetic regions containing variants associated with human cardiovascular traits. Transcriptomic analyses revealed that FURIN, PCSK5, MBTPS1 were downregulated, while PCSK6/7 were upregulated in plaques vs. control art …
Apart from PCSK4, all PCSK family members lie in genetic regions containing variants associated with human cardiovascular traits. Transcript …
Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.
Parvaz N, Jalali Z. Parvaz N, et al. PLoS One. 2021 Oct 28;16(10):e0259085. doi: 10.1371/journal.pone.0259085. eCollection 2021. PLoS One. 2021. PMID: 34710160 Free PMC article.
The results showed the positive selection to occur in PCSK1, PCSK3, PCSK5, and PCSK7. A decelerated rate of evolution was observed in PCSK7, PCSK3, and MBTPS1 in Carnivores compared to the rest of phylogeny, and an accelerated evolution of PCSK1, PCSK7, and MBTPS …
The results showed the positive selection to occur in PCSK1, PCSK3, PCSK5, and PCSK7. A decelerated rate of evolution was observed in …
Relative expression of proprotein convertases in rat ovaries during pregnancy.
Kwok SC, Chakraborty D, Soares MJ, Dai G. Kwok SC, et al. J Ovarian Res. 2013 Dec 11;6(1):91. doi: 10.1186/1757-2215-6-91. J Ovarian Res. 2013. PMID: 24330629 Free PMC article.
METHODS: RNA was extracted from ovaries at Day 0, 4, 9, 11, 13, 15, 18, and 20 of pregnancy as well as 3 days postpartum. Relative expression levels of Pcsk1, Pcsk2, Furin, Pcsk4, Pcsk5, Pcsk6, Pcsk7, Mbtps1 and Pcsk9 were determined with real-time PCR. ...On the ot …
METHODS: RNA was extracted from ovaries at Day 0, 4, 9, 11, 13, 15, 18, and 20 of pregnancy as well as 3 days postpartum. Relative expressio …
Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL.
Turpeinen H, Raitoharju E, Oksanen A, Oksala N, Levula M, Lyytikäinen LP, Järvinen O, Creemers JW, Kähönen M, Laaksonen R, Pelto-Huikko M, Lehtimäki T, Pesu M. Turpeinen H, et al. Atherosclerosis. 2011 Dec;219(2):799-806. doi: 10.1016/j.atherosclerosis.2011.08.011. Epub 2011 Aug 22. Atherosclerosis. 2011. PMID: 21889147
BACKGROUND: Proprotein convertase subtilisin/kexin (PCSK) enzymes cleave proproteins into mature end products. Previously, MBTPS1 and PCSK9 have been shown to regulate cholesterol metabolism and LDL receptor recycling, whereas FURIN and PCSK5 have been suggested to …
BACKGROUND: Proprotein convertase subtilisin/kexin (PCSK) enzymes cleave proproteins into mature end products. Previously, MBTPS1 and …
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure.
Turpeinen H, Seppälä I, Lyytikäinen LP, Raitoharju E, Hutri-Kähönen N, Levula M, Oksala N, Waldenberger M, Klopp N, Illig T, Mononen N, Laaksonen R, Raitakari O, Kähönen M, Lehtimäki T, Pesu M. Turpeinen H, et al. Hum Genet. 2015 Jun;134(6):627-36. doi: 10.1007/s00439-015-1546-5. Epub 2015 Mar 27. Hum Genet. 2015. PMID: 25813623 Clinical Trial.
To gain a comprehensive understanding of the genetic regulation of PCSK expression, we performed, for the first time, a genome-wide expression quantitative trait loci (eQTL) analysis using mRNA expression in >1400 human peripheral blood samples from the Cardiovascular Risk in …
To gain a comprehensive understanding of the genetic regulation of PCSK expression, we performed, for the first time, a genome-wide expressi …
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.
Demidyuk IV, Shubin AV, Gasanov EV, Kurinov AM, Demkin VV, Vinogradova TV, Zinovyeva MV, Sass AV, Zborovskaya IB, Kostrov SV. Demidyuk IV, et al. PLoS One. 2013;8(2):e55752. doi: 10.1371/journal.pone.0055752. Epub 2013 Feb 7. PLoS One. 2013. PMID: 23409034 Free PMC article.
Significant changes in the expression of PCs have been revealed in tumor tissues: increased FURIN mRNA level (p<0.00005) and decreased mRNA levels of PCSK2 (p<0.007), PCSK5 (p<0.0002), PCSK7 (p<0.002), PCSK9 (p<0.00008), and MBTPS1 (p<0.00004) as w …
Significant changes in the expression of PCs have been revealed in tumor tissues: increased FURIN mRNA level (p<0.00005) and decreased mR …